Avoid Medication Errors
KIRO® Oncology
“The gravimetric control method employed by KIRO® Oncology is a reliable approach for determining dosing accuracy in the automatic release of preparations, as compared to analytical control using HPLC. The variations were related to methodological differences and were considered clinically acceptable(9)”
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97,8% of the final preparations (n=3640) presented Internal Error (IE) <3% and 2,2% of the final preparations were within the limit of IE <5%(13)
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In process gravimetric control combined to products identification and traceability of each step can replace an analytical control on the final product used in the industrial approach(6)
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Admissible accuracies (-2%/+5% for reconstitution and -5%/+5% for dose withdrawal) allow to achieve a mean accuracy on the final product in the range of -4%(6)
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A total of 75 bags of paclitaxel, 75 bags of cyclophosphamide, and 30 bags of vincristine were produced. Sampling accuracy was validated across volumes ranging from 2 to 48 mL using a reliable gravimetric control(33)
